Doxorubicin-conjugated PLA-PEG-Folate based polymeric micelle for tumor-targeted delivery: Synthesis and in vitro evaluation

Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate.

For folate-receptor-targeted anti-cancer therapy, doxorubicin aggregates in a nano-scale size were produced employing doxorubicin-polyethylene glycol-folate (DOX-PEG-FOL) conjugate. Doxorubicin and folate were respectively conjugated to alpha- and omega-terminal end group of a PEG chain. The conjugates assisted to form doxorubicin nano-aggregates with an average size of 200 nm in diameter when ...

Development of an MMP2-Sensitive Folate Receptor (FR)-Targeted Polymeric Micelle for Tumor- Targeted Drug Delivery and Cancer Sensitization

Folate-conjugated nanodiamond for tumor-targeted drug delivery

Folate receptor targeted biodegradable polymeric doxorubicin micelles.

Biodegradable polymeric micelles, self-assembled from a di-block copolymer of poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), were prepared to achieve folate receptor targeted delivery of doxorubicin (DOX). In the di-block copolymer structure of PLGA-b-PEG, DOX was chemically conjugated to a terminal end of PLGA to produce DOX-PLGA-mPEG, and folate was separately conju...

Tumor-targeted drug delivery by folate conjugated amphiphiles

Drug delivery by folate conjugated amphiphiles Abstract A series of amphiphilic conjugates of folic acid and aliphatic fatty acids was designed to serve as targeted drug delivery carriers for anticancer agents. The effectiveness of targeted delivery of amphiphile was evaluated using folate receptor positive HeLa cells and Caco-2 cells that do not express folate receptor. Wild type HeLa cells we...